| Home | Score | Away | League | Time (CST) |
|---|---|---|---|---|
| Sporting JAX | 0:0 | Pittsburgh Riverhounds | American USL Championship | 07:30 |
| The Strongest | 0:0 | Oriente Petrolero | Bolivian Primera División | 08:00 |
| One Knoxville | 1:0 | Fort Wayne FC | American USL League One | 06:30 |
| Universidad Católica del Ecuador | 1:0 | LDU Quito | Ecuadorian Serie A | 06:00 |
| Leones | 1:1 | Deportivo Cuenca | Ecuadorian Serie A | 06:00 |
| Real Potosí | 5:0 | San Antonio Bulo Bulo | Bolivian Primera División | 06:00 |
| Miami FC | 1:0 | Indy Eleven | American USL Championship | 07:00 |
| New England Revolution II | 1:2 | Columbus Crew 2 | MLS Next Pro | 07:00 |
| Lexington SC | 0:2 | New Mexico United | American USL Championship | 07:00 |
| Chattanooga Red Wolves | 1:0 | AV Alta FC | American USL League One | 07:00 |
